Aspergillus galactomannan antigen in the cerebrospinal fluid of bone marrow transplant recipients with probable cerebral aspergillosis.
نویسندگان
چکیده
The Aspergillus galactomannan test was performed on cerebrospinal fluid and serum samples from 5 patients with probable cerebral aspergillosis and from 16 control patients. Cerebrospinal fluid galactomannan levels were significantly higher in aspergillosis patients, and most galactomannan was produced intrathecally. Comparison of serum galactomannan values in pulmonary and cerebral aspergillosis patients showed significant overlapping. Detection of Aspergillus galactomannan in cerebrospinal fluid may be diagnostic of cerebral aspergillosis.
منابع مشابه
ارزیابی سطح سرمی آنتی ژن گالاکتومانان به منظور تشخیص آسپرژیلوزیس مهاجم در بیماران مبتلا به بدخیمی های خونی و گیرندگان پیوند مغز استخوان
Background and purpose: Invasive aspergillosis, is a serious fatal disease caused by fungal species of Aspergillus in patients with neutropenia, bone marrow transplant recipients, patients with blood disorders, chronic granulomatous disease, recipients of long-term steroids or antibiotics. Galactomannan antigen (GM) is a polysaccharide of Aspergillus present in the cell wall of Aspergillus spp....
متن کاملComparison of an Aspergillus real-time polymerase chain reaction assay with galactomannan testing of bronchoalvelolar lavage fluid for the diagnosis of invasive pulmonary aspergillosis in lung transplant recipients.
BACKGROUND Early diagnosis and treatment of invasive pulmonary aspergillosis (IPA) improves outcome. METHODS We compared the performance of publicly available pan-Aspergillus, Aspergillus fumigatus-, and Aspergillus terreus-specific real-time polymerase chain reaction (PCR) assays with the Platelia galactomannan (GM) assay in 150 bronchoalveolar lavage (BAL) samples from lung transplant recip...
متن کاملFungal infections in marrow transplant recipients under antifungal prophylaxis with fluconazole.
Fungal infection is one of the most important causes of morbidity and mortality in bone marrow transplant (BMT) recipients. The growing incidence of these infections is related to several factors including prolonged granulocytopenia, use of broad-spectrum antibiotics, conditioning regimens, and use of immunosuppression to avoid graft-versus-host disease (GvHD). In the present series, we report ...
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We have evaluated the Platelia Aspergillus enzyme immunoassay for detection of galactomannan in bronchoalveolar lavage (BAL) specimens in solid organ transplant patients with aspergillosis. The precision and reproducibility in serum or BAL to which galactomannan was added were similar. Sensitivity was 81.8% in patients with aspergillosis, and specificity was 95.8% in lung transplant patients wh...
متن کاملGalactomannan and 1,3-β-d-Glucan Testing for the Diagnosis of Invasive Aspergillosis
Invasive aspergillosis (IA) is a severe complication among hematopoietic stem cell transplant recipients or patients with hematological malignancies and neutropenia following anti-cancer therapy. Moreover, IA is increasingly observed in other populations, such as solid-organ transplant recipients, patients with solid tumors or auto-immune diseases, and among intensive care unit patients. Freque...
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ورودعنوان ژورنال:
- Journal of clinical microbiology
دوره 40 4 شماره
صفحات -
تاریخ انتشار 2002